iindaba

Ngokusekwe kwi-aza-BODIPY skeleton, i-NIR1001 idibanisa amaqela anikela nge-electron (umzekelo, i-4-N, N-diphenylaminophenyl) kwi-2,6-positions, eyenza i-symmetric D-π-D structure1. Olu yilo lunciphisa i-gap ye-HOMO-LUMO, ukuguqula i-absorption peak ngaphaya kwe-1000 nm kunye nokuphucula ukudluliselwa kwentlawulo ye-intramolecular (ICT). Kwi-THF, i-NIR1001 ibonisa ubuninzi be-photon absorption (TPA) ye-cross-section ye-37 GM, uphuculo oluphindwe kabini ngaphezu kwezinto eziphuma kwi-BODIPY eziqhelekileyo. Ubomi bayo obuvuyisayo be-1.2 ps buvumela utshintsho olungasebenziyo lwe-radiative, luyenze ilungele unyango lwe-photodynamic (PDT).

Ubalo lwe-DFT lubonisa ukuba indlela yogqithiselo lwentlawulo ye-NIR1001 ivela kwi-π-electron delocalization phakathi komnikeli kunye nemoieti yokwamkela. Ukuguqulwa kwe-Methoxy kwandisa ngakumbi ukufunxa kwe-NIR kwifestile ye-phototherapeutic (650-900 nm), ukuphucula ubuntununtunu1. Xa kuthelekiswa nedayi ye-AF yeYunivesithi yaseFudan, i-NIR1001 igcina ubunzima obuncinane be-molecular (<500 Da) kunye ne-40% ephezulu ye-photostability. Ukuguqulwa kweCarboxylation kuphucula ukunyibilika kwamanzi (cLogD=1.2), ukunciphisa i-adsorption engangqalanga kwiinkqubo zebhayoloji

3. Izicelo zeBiomedical
Kwi-bioimaging, i-hCG-conjugated probe hCG-NIR1001 ifezekisa i-high-resolution imaging ye-ovarian follicles kunye ne-micro-metastases phantsi kwe-808 nm excitation. Ngobunzulu bokungena obuyi-3 cm kwi-NIR-II, idlula i-NIR-I probes ngokuphindwe kathathu, ngelixa inciphisa i-fluorescence yangasemva ngama-60%. Kwimodeli yokulimala kwezintso zemouse, i-NIR1001 ibonisa i-85% ye-renal-specific uptake, ibona umonakalo ophindwe kathandathu ngokukhawuleza kunolawulo lwe-macromolecular.
I-PDT, i-NIR1001 ivelisa iintlobo ze-oksijini ezisebenzayo (ROS) kwi-0.85 μmol / J phantsi kwe-1064 nm laser irradiation, ngokufanelekileyo ibangela i-apoptosis yeseli ye-tumor. I-Liposome-encapsulated i-NIR1001 nanoparticles (NPs) iqokelela amaxesha angama-7.2 ngaphezulu kwamathumba kunedayi yamahhala, ukunciphisa imiphumo ekujoliswe kuyo.
4. Ukubekwa esweni kwemizi-mveliso kunye nokusiNgqongileyo
Kusetyenziso lwemizi-mveliso, i-NIR1001 idityaniswe kwi-Juhang Technology's SupNIR-1000 analyzer yokuhlela iziqhamo, ukuhlolwa komgangatho wenyama, kunye nokulungiswa kwecuba. Isebenza kuluhlu lwe-900-1700 nm, ngaxeshanye ilinganisa umxholo weswekile, umswakama, kunye neentsalela ze-pesticide ngaphakathi kwemizuzwana ye-30 ngokuchaneka kwe-± (50ppm + 5%). Kwi-automotive CO2 sensors (ACDS-1001), i-NIR1001 yenza ukuba iliso lexesha langempela kunye nexesha lokuphendula le-T90≤25s kunye nexesha le-15 leminyaka.
Ukuchongwa kwendalo, i-NIR1001-i-probes esebenzayo ibona isinyithi esinzima emanzini. Kwi-pH 6.5-8.0, ukuqina kwe-fluorescence ngokuhambelana ngokuhambelana ne-Hg²⁺ yoxinaniso (0.1-10 μM) kunye nomda wokubhaqa we-0.05 μM, iindlela ezisebenza ngokugqithisileyo zombala ngee-odolo ezimbini zobukhulu.
5. Ukusungula iTekhnoloji kunye noRhwebo
Qingdao Topwell Materialsusebenzisa i-synthesis eqhubekayo ukuvelisa i-NIR1001 kwi-99.5% yobunyulu, kunye ne-50 kg / umthamo webhetshi. Ukusebenzisa i-microchannel reactors, ixesha le-Knoevenagel condensation liyancitshiswa ukusuka kwiiyure ze-12 ukuya kwimizuzu engama-30, ukunciphisa ukusetyenziswa kwamandla ngama-60%. I-ISO 13485-certified NIR1001 series ilawula i-biomedical market.